Intelligence · Ingredients

The ingredient narratives reshaping clean beauty.

Copper Peptides (GHK-Cu)

aka ghk-cu · ghk · copper tripeptide-1 · glycyl-histidyl-lysine copper

GHK-Cu — glycyl-histidyl-lysine bound to copper — is a naturally occurring tripeptide-copper complex with three decades of wound-healing and anti-aging research. The Ordinary's Buffet + Copper Peptides 1% put it on the mass map; Niod CAIS 2 and Skin Biology's Dr. Pickart formulations anchor the prestige tier. 2024–2025 saw GHK-Cu re-emerge as the premium anti-aging signal molecule beyond retinol.

Benefits
  • stimulates collagen, elastin, and GAG synthesis
  • wound-healing and post-procedure repair
  • antioxidant via SOD-like activity
Example uses
  • Niod CAIS 2
  • The Ordinary Buffet + Copper
  • Skin Biology Super Cop
Formulation notes

Effective at 0.05–2% in serums; the characteristic blue color is the signature. pH 5–7 for stability. Avoid co-formulating with strong vitamin C (chelation), high-dose niacinamide (debated), or AHAs in the same routine — alternate AM/PM.

Watchouts

'Copper peptide' marketing is broad — many products use cheaper analogues (acetyl tetrapeptide-2 + copper salt) that are not GHK-Cu. Look for GHK-Cu specifically named.

Clean beauty perception

Strongly positive in the clean-clinical crossover.