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Sodium Hyaluronate (HA Molecular-Weight Series)

aka sodium hyaluronate · low molecular weight ha · high molecular weight ha · ha multi-weight

The salt form of hyaluronic acid — what 'HA' on most clean labels actually means. The 2024–2025 sophistication is the multi-MW serum: combining ultra-low MW (≈5 kDa, deeper penetration), low MW (~50 kDa), medium MW (~1 MDa), and high MW (>1 MDa, surface film) for layered hydration. Vichy Minéral 89, Skinceuticals H.A. Intensifier, and The Ordinary's Multi-Peptide HA all formalize the multi-weight approach.

Benefits
  • graded hydration from surface film to upper-dermal depth
  • ultra-low MW fragments may signal repair (controversial but emerging data)
  • compatible with virtually any skincare system
Example uses
  • multi-MW hydration serums
  • post-acid recovery
  • injectable-adjacent topical 'HA boosters'
Formulation notes

0.1–2% per MW fraction; total HA in a serum rarely exceeds 2% by weight. Crosslinked HA (in injectables and a few topical wraps) is a distinct category. Pairs with NMF (PCA, glycerin), peptides, and ceramides.

Watchouts

Low-humidity climates: HA without an occlusive can pull water from the dermis upward and outward, leaving skin drier. Always seal with a cream or oil.

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