The ingredient narratives reshaping clean beauty.
Palmitoyl Tripeptide-1 / Tripeptide-1
aka pal-ghk · palmitoyl tripeptide-1 · matrixyl 3000 · palmitoyl tetrapeptide-7
The signal-peptide workhorse — Sederma's pal-GHK (palmitoyl-glycyl-histidyl-lysine), often blended with palmitoyl tetrapeptide-7 as the Matrixyl 3000 complex. Drives the 'peptide' shelf at every clean-prestige line from Drunk Elephant Protini to Olay Regenerist to Naturium Multi-Peptide. 2025's peptide-stack era treats tripeptide-1 as the foundation collagen-signal, paired with copper peptides, neuropeptides (argireline), and barrier-support biomimetic proteins.
- stimulates type I and III collagen and fibronectin synthesis
- well-tolerated, no irritation
- stacks productively across peptide families
- Drunk Elephant Protini
- Olay Regenerist
- Naturium Multi-Peptide Eye Cream
Effective at 2–8% of the Matrixyl 3000 blend (which is itself ~100 ppm of active peptide). pH 5–7. Pairs with copper peptides, niacinamide, panthenol, ceramides. The palmitoyl chain improves stratum corneum penetration.
'Peptides' on a label is broad — Matrixyl 3000 / pal-GHK is one of many. Real efficacy needs 8–12 weeks of sustained use.
Strongly trusted as the foundational clean-credentialed peptide.
The ingredient narratives reshaping clean beauty.
Palmitoyl Tripeptide-1 / Tripeptide-1
aka pal-ghk · palmitoyl tripeptide-1 · matrixyl 3000 · palmitoyl tetrapeptide-7
The signal-peptide workhorse — Sederma's pal-GHK (palmitoyl-glycyl-histidyl-lysine), often blended with palmitoyl tetrapeptide-7 as the Matrixyl 3000 complex. Drives the 'peptide' shelf at every clean-prestige line from Drunk Elephant Protini to Olay Regenerist to Naturium Multi-Peptide. 2025's peptide-stack era treats tripeptide-1 as the foundation collagen-signal, paired with copper peptides, neuropeptides (argireline), and barrier-support biomimetic proteins.
- stimulates type I and III collagen and fibronectin synthesis
- well-tolerated, no irritation
- stacks productively across peptide families
- Drunk Elephant Protini
- Olay Regenerist
- Naturium Multi-Peptide Eye Cream
Effective at 2–8% of the Matrixyl 3000 blend (which is itself ~100 ppm of active peptide). pH 5–7. Pairs with copper peptides, niacinamide, panthenol, ceramides. The palmitoyl chain improves stratum corneum penetration.
'Peptides' on a label is broad — Matrixyl 3000 / pal-GHK is one of many. Real efficacy needs 8–12 weeks of sustained use.
Strongly trusted as the foundational clean-credentialed peptide.